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Orochimaru
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Orochimaru (大蛇丸, Orochimaru) is a major antagonist of the Naruto series during Part I and a secondary antagonist during Part II. Recognised as one of the most powerful ninja Konohagakure ever produced and one of the "Three Legendary Shinobi" (伝説の三忍, Densetsu no Sannin), he operated as an ANBU shinobi in the village within the Root faction prior to his defection from the village in pursuit of his own self-serving ambitions. Initially sealed away during the battle between Sasuke and Itachi by the latter, he was later revived by the former using his own genetic material that was within his subordinate Kabuto Yakushi and the portion of consciousness he left within Anko Mitarashi's Cursed Seal of Heaven.

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