Chiyo, often called "Honoured Grandmother Chiyo" (チヨバア様, Chiyo-baasama) by the Sunagakure villagers, was the village's poison and puppet expert. She and her brother Ebizo were highly revered in Sunagakure and were known as the "Honoured Siblings" (御姉弟, Gokyōdai). Chiyo was very knowledgeable when it came to handling poisons and used her skills often during the Second Shinobi World War, only to be countered numerous times by Tsunade's medical expertise. This caused Chiyo to hold a grudge against Tsunade, who she came to call "that slug-girl" (あのナメクジ娘, Ano Namekuji-musume), or the "Slug Princess" in the English translations. During the war, she also fought Hanzo and his salamander numerous times, learning how frequently it can use its venom and eventually developing an antidote against it. She was killed when she had gave her live to revive Gaara after his tailed beast was extracted, but she was later revived in the Fourth Shinobi World War.